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2016年7月22-28日在加拿大多倫多召開的2016年阿爾茨海默病協(xié)會(huì)國際會(huì)議（AAIC））上，兩項(xiàng)研究一致表明：阿爾茨海默病經(jīng)常被誤診，尤其是男性患者。 在第一項(xiàng)研究中，來自美國梅奧診所的Melissa Murray, Ph.D.及其研究團(tuán)隊(duì)發(fā)現(xiàn)，與女性相比，男性患者可能更容易被誤診?；诜鹆_里達(dá)州腦庫數(shù)據(jù)，研究者對(duì)1,606名阿爾茨海默病患者的大腦進(jìn)行分析（年齡范圍37-102歲）。 男性患者誤診率更高的原因之一可能是與女性相比，男性的發(fā)病年齡更早，病情也更重。Murray博士指出，男性大多在60多歲出現(xiàn)阿爾茨海默病，而女性大多至70歲、80歲甚至90歲才發(fā)病。此外，男性往往會(huì)出現(xiàn)有別于女性的疾病相關(guān)大腦病變，其癥狀表現(xiàn)不同于女性，這可能也是導(dǎo)致男性患者被誤診的原因之一。Murray博士補(bǔ)充道，男性患者的癥狀可能包括行為癥狀，或者言語困難或運(yùn)動(dòng)問題，而非阿爾茨海默病常見的記憶障礙。 在第二項(xiàng)研究中，來自多倫多圣米高醫(yī)院Keenan生物醫(yī)學(xué)研究中心的研究者，對(duì)加拿大國家阿爾茨海默病協(xié)調(diào)中心數(shù)據(jù)庫1,073例病例中臨床診斷與尸檢診斷不符的情況進(jìn)行分析。 研究團(tuán)隊(duì)發(fā)現(xiàn)，78.4%的患者臨床診斷準(zhǔn)確，與最后的尸檢結(jié)果相吻合。然而，10.8%被臨床診斷為阿爾茨海默病的患者，實(shí)際上未患該疾病。此外，10.8%未被臨床診斷為阿爾茨海默病的患者其實(shí)患有此疾病。 Alzheimer's disease is often misdiagnosed,possibly more so in men, two new studies reveal. The results of both studies were presented at the annual Alzheimer's Association International Conference,held from July 22 to 28 in Toronto. In the first study, a team of researchers from the Mayo Clinic in Jacksonville, Fla., led by Melissa Murray, Ph.D., foundthat men may be misdiagnosed more often than women. This study included information from the State of Florida brain bank. The researchers examined 1,606 brains of Alzheimer's patients ranging in age from 37 to 102. One reason for a higher rate of misdiagnosis in men may be that men in the study seemed to develop Alzheimer'sat a younger age than women and had a more aggressive form of the disease. Mentended to develop Alzheimer's in their 60s, while women developed it in their70s, 80s, and 90s, Murray told HealthDay. Men also seemed to have different disease-related brain pathology than women. This may account for the misdiagnosis among men, because their symptoms can be different than those of women, Murray said. She added that men's symptoms may be behavioral, or theremay be language difficulty or motor problems instead of the memory problemsusually associated with Alzheimer's. In the second study, researchers from the Keenan Research Centre for Biomedical Science at St. Michael's Hospital inToronto looked at inconsistencies between clinical and autopsy diagnoses in 1,073 individuals listed in the National Alzheimer's Coordinating Center database. The team found that 78.4 percent of the patients had a correct diagnosis in the clinic, which was later confirmed in an autopsy of the brain.However, 10.8 percent of those diagnosed with Alzheimer's in the clinic didn'thave the disease. And, another 10.8 percent who weren't diagnosed withAlzheimer's actually had the disease.
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