The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study

術(shù)后咽喉痛（POST）是氣管插管后的常見表現(xiàn)，而口服鋅可預(yù)防與化療相關(guān)的口腔黏膜炎。本研究旨在評估鋅錠劑對POST的影響。

把接受氣管插管后行低風(fēng)險或中風(fēng)險手術(shù)的79例患者隨機(jī)分為兩組：給予安慰劑的對照組和術(shù)前30分鐘給予40mg鋅錠劑的鋅組。在術(shù)后0,2,4,24小時后評估患者POST的發(fā)生率和嚴(yán)重程度（4點(diǎn)量表，0-3）。主要結(jié)局為術(shù)后4小時POST的發(fā)生率。次要結(jié)局為術(shù)后0，2和24小時后POST發(fā)生率和嚴(yán)重程度。

4小時后，鋅組POST的發(fā)生率7%明顯低于對照組29%（P=0.046）。鋅組在術(shù)后即刻POST的發(fā)生率為0%，對照組為24%（P=0.004）。術(shù)后2小時為POST的高發(fā)期，鋅組為10%，對照組為34%（P=0.0495）。24小時后鋅組POST的發(fā)生率為13%，對照組為24%（無統(tǒng)計(jì)學(xué)差異）。鋅組術(shù)后輕度（P=0.003）和中度（P=0.004）的POST明顯減少。

術(shù)前30分鐘給予單次劑量為40mg鋅錠劑可以有效地減少術(shù)后4小時POST的發(fā)生率和在術(shù)后即刻輕中度POST的嚴(yán)重程度。

原始文獻(xiàn)摘要

Farhang B, Grondin L.The Effect of Zinc Lozenge on Postoperative Sore Throat: A Prospective Randomized, Double-Blinded, Placebo-Controlled Study, Anesth Analg. 2017 Sep 25. doi: 10.1213/ANE.0000000000002494.

BACKGROUND:

Postoperative sore throat (POST) is commonly seen after endotracheal intubation, and oral zinc prevents oral mucositis associated with chemotherapy. This study is designed to evaluate the effects of administration of zinc lozenges on POST.

METHODS:

Seventy-nine patients undergoing low- or moderate-risk surgery with endotracheal intubation were randomly assigned into 2 groups: Control group received placebo and zinc group received 40-mg zinc lozenges 30 minutes preoperatively. Patients were assessed for incidence and severity (4-point scale, 0-3) of POST at 0, 2, 4, and 24 hours postoperatively. The primary outcome was incidence of POST at 4 hours after surgery. The secondary outcomes were the incidence of POST at 0, 2, and 24 hours and the severity of POST.

RESULTS:

At 4 hours, there was a significantly lower incidence of POST in the zinc group, 7%, than the control group, 29% (P = .046). The incidence of POST at 0 hour was 0% in zinc group and 24% in control group (P = .004). The highest incidence of POST occurred at the second hour after surgery, with the rate of 10% in the zinc group and 34% in the control group (P = .0495). The incidence of POST at 24 hours was 13% in zinc group and 24% in control group (not significant). The severity of POST was significantly lower in the zinc group for mild (P = .003) and moderate (P = .004) POST.

CONCLUSIONS:

The administration of a single dose of 40-mg zinc lozenge 30 minutes preoperatively is effective to reduce both incidence of POST in the first 4 hours and severity of mild and moderate POST in the immediate postoperative period.